Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon
نویسندگان
چکیده
منابع مشابه
Neurobehavioral evaluation of adolescent male rats following repeated exposure to chlorpyrifos.
Chlorpyrifos (CPF), a highly effective organophosphate pesticide (OP), is extensively used worldwide. However, its agricultural use was extensively reduced in 2001. Several studies have suggested an association between mood disorders and CPF exposure in humans, especially in children, a subgroup that is highly susceptible to xenobiotics. We investigated the hypothesis that repeated CPF exposure...
متن کاملNeurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats.
Acute exposure to the organophosphate pesticide chlorpyrifos (CPF) on gestation day 12 (GD12, 200 mg/kg/ml, SC) causes extensive neurochemical changes in maternal brain but lesser changes in fetal brain. In the present study, we examined the relative neurotoxicity of repeated, lower-level CPF exposures during gestation in rats. Pregnant Sprague-Dawley rats were exposed to CPF (6.25, 12.5, or 25...
متن کاملNeurobehavioral effects of chronic dietary and repeated high-level spike exposure to chlorpyrifos in rats.
This study aimed to model long-term subtoxic human exposure to an organophosphorus pesticide, chlorpyrifos, and to examine the influence of that exposure on the response to intermittent high-dose acute challenges. Adult Long-Evans male rats were maintained at 350 g body weight by limited access to a chlorpyrifos-containing diet to produce an intake of 0, 1, or 5 mg/kg/day chlorpyrifos. During t...
متن کاملAbiotic transformation of chlorpyrifos to chlorpyrifos oxon in chlorinated water.
In vivo transformation of chlorpyrifos to chlorpyrifos oxon is believed to be a prerequisite for this insecticide to display acute toxicity to organisms. We discovered that active chlorine dispersed in water causes the rapid abiotic transformation of chlorpyrifos to chlorpyrifos oxon. The proposed mechanism for the transformation is an electrophilic attack by hypochlorous acid (HOCl) on the thi...
متن کاملThe effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure.
Chlorpyrifos (CPS) is a widely used diethyl organophosphorus insecticide in agricultural settings. Household and urinary residue analysis has suggested that children in agricultural communities are at risk of exposure to diethyl organophosphorus insecticides. The effects of repeated postnatal exposure to CPS and its metabolite chlorpyrifos-oxon (CPO) on total muscarinic acetylcholine receptor (...
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ژورنال
عنوان ژورنال: Neurotoxicology and Teratology
سال: 2012
ISSN: 0892-0362
DOI: 10.1016/j.ntt.2012.02.003